Jesse Evans

Support my challenge for kids facing cancer.

Every month in Australia, 90 children are diagnosed with cancer.  

Myself and son both have a rear disease only 3%of the world have Li-Fraumeni sydome.

Individuals with LFS  have a lifetime risk of approximately 60-80% for colorectal cancer.

Increased risk for endometrial (uterine) cancer, ovarian cancer, stomach cancer, small intestine cancer, and others.Li-Fraumeni Syndrome (LFS) is a rare inherited genetic disorder that significantly increases the risk of developing certain types of cancer, particularly at a young age. Here are the key points about Li-Fraumeni Syndrome:

1. **Genetic Basis**: LFS is typically caused by mutations in the TP53 gene, which is essential for tumor suppression and regulating cell division. While most cases are inherited in an autosomal dominant manner, new mutations can also occur.

2. **Cancer Risks**: People with Li-Fraumeni Syndrome face a higher risk of various cancers, including:

   - Breast cancer

   - Soft tissue sarcomas

   - Osteosarcoma (bone cancer)

   - Brain tumors

   - Adrenal gland tumors

   These cancers can occur at any age, but they are often diagnosed in childhood or young adulthood.

3. **Diagnosis**: LFS is diagnosed based on clinical criteria, which include a family history of cancers associated with the syndrome, particularly if they occur at a young age. Genetic testing for TP53 mutations can confirm the diagnosis.